Evariste is an AI-driven Drug Discovery company
Evariste identifies and validates novel biomarkers to customize treatment to the patient
Evariste’s algorithmic modeling designs higher quality, differentiated molecules
Highly Automated R&D
Evariste has automated preclinical drug discovery enabling unprecedented scale and efficiency
Our AI-enabled platform de-risks and progresses projects with unrivaled efficiency
Each stage of our platform has been validated in challenging internal and collaborative projects
Synthetic Lethal Gene Signatures
At Evariste we have developed the novel concept of synthetic lethal gene signatures, small panels of multi-omic biomarkers which reveal untargeted synthetic lethal interactions together with the patient population for which drugs targeting these genes will be most effective.
Our AI platform applies proprietary algorithms to large multi-omic biological and chemical datasets, including proprietary and public data. Targets are validated in disease-relevant models to ensure their clinical applicability. We identify specific predictive biomarkers or novel synthetic lethalities to ensure that the right patients will receive our treatments.
To translate the insights from our AI target ID platform the Evariste Hit Discovery platform utilises information-rich hit finding tools to maximise the speed and success of ligand discovery.
We search ultra large libraries for hit-like chemical matter using statistically robust proprietary scoring functions. Probabilistic algorithms exploit the structure of combinatorial libraries, and facilitate virtual screening of libraries consisting of trillions of diverse compounds. The output of our screen is a diverse set of compounds in energetically favorable conformations hyper-enriched in key protein-ligand interactions.
We have successfully applied covalent fragment screens to find novel hit matter for previously undrugged protein families and target classes. The vast quantities of data generated by this technique maximises the speed of downstream development.
The Evariste Hit-to-Candidate platform designs and scores synthetically accessible molecules on a scale that would not be feasible for a team of chemists. Probabilistic modeling allows for principled combination of multiple endpoints, facilitating multi-parameter optimization. Our machine learning models are ideally suited to drug discovery as they are designed to work on small, noisy datasets.
The platform stands out not just for its ability to design synthetically accessible molecules, but also for its efficiency and efficacy. Through advanced statistical compound selection techniques, the platform consistently achieves a 10-fold increase in potency for every set of 30 compounds tested. Furthermore, in fewer than 50 compounds it has designed compounds with best-in-class selectivity against targets that are highly homologous. This level of precision and rapid optimization positions the Evariste platform at the forefront of drug discovery, offering a transformative approach in an era where fast and efficient compound development is paramount.
Targeting PKMYT1 drives synthetic lethality in CCNE1 over-expressing cell lines, with clinical trials ongoing to explore this hypothesis. We have identified a novel biomarker for PKMYT1 synthetic lethality with potential for a significantly expanded patient population, and designed novel inhibitors with high potency and selectivity.
Small molecule inhibitors of c-MET have recently been approved in a subset of NSCLC patients. As is typical for novel oncology drugs, resistance develops rapidly, causing relapse and disease progression. In collaboration with Arctoris we have developed best-in-class 2nd generation c-MET inhibitors with selectivity over key off-targets.
Undisclosed - DLBCL
Undisclosed target for heavily pretreated hematological malignancies. We have identified a new synthetic lethal target in a subset of acute myeloid leukemia and diffuse large B-cell lymphoma patients. This target is extremely novel and no enzymes of this class have been targeted with small molecule inhibitors or biologics.
Undisclosed - CCNE1 Addiction
A well-validated target with a clearly defined patient population, also showing significant promise as a second line therapy in a resistant patient population, and in combination with hormone therapy in breast cancer. We have identified potentially best-in-class compounds despite synthesising only 50 molecules.
Undisclosed - Synthetic Lethal
A well-validated target that is currently in clinical trials without a clear biomarker strategy. We have identified a novel synthetic lethal partner to allow rapid patient selection and have designed inhibitors with best-in-class potency and selectivity.
10+ AI Synthetic Lethals
A pipeline of next generation synthetic lethal targets with experimental validation across multiple cancer subtypes and a clear patient selection strategy.
We work in collaboration with biotech companies to accelerate the development of small molecules for a range of target classes in diverse disease areas. Our AI platform is able to support and advance discovery at every stage of preclinical development.
For any collaboration or business development inquiries:
March 18, 2022
Automated design of potent antimalarials
The OpenSource Malaria project team used a tool called Frobenius to design and synthesize novel anti-malarial compounds.
April 6, 2021
Frobenius 2.0: Optimising towards potent, soluble antimalarials
Discover Frobenius 2.0, a tool for optimising the development of effective and soluble antimalarial drugs.